Sulbutiamine (or Arcalion) is a nootropic that mainly serves to produce energy by affecting Glutamine, Dopamine, and Acetylcholine receptor sites. It is responsible for providing a proper energy metabolism within your brain.
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Its effect could be compared with the battery producing energy which allows your brain to work fast, enhance cognitive functions, and get enough energy neurons to need to do their job.
Sulbutiamine accelerates a process of carbohydrates conversion into energy used further by your neurons. And there is one amino acid required for this process, called Thiamine (a water-soluble vitamin B).
The main Thiamine’s function is to get all enzymes together and to use them for carbohydrates metabolize.
Sulbutiamine is a mighty energy supplier which keeps a certain level of energy according to the demand for brain activities.
Cognitive processes that are normally have only one source of energy (glucose) for their functioning are now boosted enough to run fast and enhance all related processes enabling you to become much more focused, concentrated, and accurate to details that are usually overlooked.
Thus by taking Sulbutiamine (Arcalion), you attain a clear mind, consistent and logical thinking, and unlike any other brain stimulators, Sulbutiamine brings you benefits with no such side effects like trembling, shivering, stress, or hyperactivity.
It is mainly used for diabetes, hypothyroidism, fatigue, fibromyalgia, depression, and others (explained in detail further).
Usage of this nootropic is essentially related to increasing functions of neurons and brain activity when lots of energy is required: thought process, memory, concentration, learning capacity, attentiveness, accelerate reaction, and reflexes.
Sulbutiamine is often applied to cure chronic fatigue, asthenia (alleviation is proved by clinical trials), depression, and anxiety.
Indirect positive effects of Sulbutiamine are: it makes you feel less anxious, relief from shyness, social phobias, helps reduce body weight, and even erectile dysfunction (this one is questionable).
Sulbutiamine is also used for the treatment of depression and as a motivation booster. Desired effects are sensitively related to a proper dose of Sulbutiamine.
One might be interested in Sulbutiamine’s additional effect which can be really useful – an improvement of erectile dysfunction.
As there are no clinical examinations that can reliably confirm or dispel this effect, there was a series of studies that confirm the effectiveness of Sulbutiamine for erectile dysfunction (you may know about these studies from here).
50% of the test audience actually confirmed that taking Sulbutiamine during 30 (thirty) consecutive days indeed made them feel much better in the context of this topic.
This effect can probably be related to the impact of Sulbutiamine on energy-boosting and poor circulation.
Sulbutiamine Right Dosage
The first thing when you start using Sulbutiamine is to recognize the right dosage, which might be difficult to understand at first.
As far as this drug is related to the amounts of energy you used for your daily activities (intensive or not). The dosage may vary depending on your activities and, of course, any other supplements being taken along with Sulbutiamine.
For some people, a sufficient dose is not more than 200 mg twice a day (mostly for normal energy-consuming life activities like everyday work).
In case of high brain activity (long periods of studies, exams, analytical work, etc.) the recommended daily dosage will be about 800 mg per day maximum (some other sources say about the maximum dosage of 600 mg (!) hence you need to consult with a doctor if the dosage of 600 mg is exceeded).
Sometimes you need a therapist’s consultation, as Sulbutiamine’s side effects could be caused by individual intolerance of the drug even with a low dosage. This moment should also be remembered.
There are also two important things regarding the usage of this cognitive enhancer.
Sulbutiamine shall not be combined with other supplements or medicaments for depression, and the second one, – taking it with milk, or Omega 3 compounds or meal.
This is a common precaution you may find in the standard description for this drug.
But the most interesting one will be specified below.
Sulbutiamine Side Effects
The majority of nootropics are reported to have minor side effects, and most of them do not bother users.
Sulbutiamine is also one of a few nootropics having a very low risk of any side effects, well-tolerated, and in most cases, people are free from any negative impact at all.
If any side effects occur, most likely it’s one of the following: dermatitis appeared by skin rashes, mood disorder, sleeping problems, and lack of appetite (a majority of cases).
But in some particular cases, you may see that taking Sulbutiamine is followed by some unusual effects which are not typical of other nootropics.
Sulbutiamine (unlike the other nootropics) has a number of rare negative effects which are headaches, dermatitis, irritation, renal failure, conjunctivitis, lupus symptoms, anxiety, epidermolysis, and increased levels of uric acid.
However, these side effects might be expressed as an unexpected result of taking Sulbutiamine considering that some of them are, in fact, the symptoms that Sulbutiamine was designed to cure (especially regarding anxiety as well as an allergic reaction).
And these effects are not exclusive ones, some users have reported swelling, hives, tightness in the chest, difficulty breathing, sleep, and others.
Based on the information above, this nootropic should be used consciously and carefully with prior consultation with your doctor.
There are some precautions that should be considered while taking Sulbutiamine.
Admittedly, each side effect has a low possibility to occur, and the best way to avoid any of them is to follow the dose instructions and not to mix it with other nootropics having similar effects (anti-depressant, anxiety treatment, etc.).
It is strongly recommended not to use Sulbutiamine by individuals having a bipolar mood disorder and/or receiving treatment for any bipolar mood disorder, as it may exacerbate this particular condition.
Moreover, there is an important thing to remember – Sulbutiamine taken in combination with medications for mental disorders may aggravate these diseased states.
In case if you still experience any side effects you should either stop or reduce dosage and immediately consult with your doctor.
As a general recommendation, it is advised to make intervals in taking this nootropic even if you have been using it for a long period with no side effects at all.
Sulbutiamine Tolerance Risk
As far as this drug interacts with Dopamine by suppressing your natural brain Dopamine release, increasing the stimulation of dopamine D1 receptors, and the relevant levels of Dopamine receptor activity, this usually leads to tolerance issues and mood disorder.
But this is only an opinion and apparently not absolutely all experts have the same position on that. With respect to the tolerance issues, it should be noted that different reviews provide contradictory information.
One of them says that this drug could be addictive, another – that the addiction is directly related to an overdosage.
Considering that we don’t know for sure how nootropics actually work, some believe that there is no direct link between suppression of Dopamine activity and tolerance, some believe that there is.
In any case, if you want to use it safely and not to test this theory on yourself, simply exclude high doses of Sulbutiamine.
Even if you failed to avoid addiction, it would be good news for you as any tolerance problems regarding Sulbutiamine are easily solved by reducing a dose, rescheduling a period of taking this drug, taking it with intervals, or stopping using it for a while.
A great decision would be to interchange Sulbutiamine with another nootropic in order to ruin any pattern which is usually learned quickly by your brain, not giving time to your brain to adjust enough for obtrusion and developing tolerance.