Can Nootropics Help with Weight Loss?

nootropics for weight loss

Recently nootropics have been praised for their strong ability to increase cognitive performance, motivation, and mood in users. However, did you know that some clinical trials now show that certain nootropics are effective for weight loss?

There are several things to consider before trying a nootropic for weight loss and in this article, we will go over everything you need to find your perfect supplements.

As well as their strong effect on cognition, nootropics are becoming more and more well-known by office workers for their ability to enhance workout intensity, improve focus, and overall performance.

It is no doubt that nootropics can play a key role in our ability to place attention on specific tasks, however many fitness gurus are now advocating the use of certain nootropics for the purpose of improving overall workout effectiveness and weight loss.

Can this be true? Let’s look into what science has to say about the effectiveness of nootropics for weight loss.

Disclaimer: you are reminded that this guide is not for the purpose of medical treatment and before taking any supplements it is advised that you consult a healthcare professional.

Can Nootropics Help with Weight Loss?

A 2010 study titled “Citicoline Affects Appetite and Cortico-Limbic Responses to Images of High-Calorie Foods” looked at the relationship between nootropics and weight loss supplements to uncover some interesting details behind what may happen following ingestion.

The primary test molecule was citicoline, a popular compound known for the ability to enhance dopamine in cocaine-addicted subjects and greatly assist with recovery addiction. The groups were split into 2 with individuals either receiving 500 mg or 2000 mg of Citicoline.

It was then observed that the group receiving a larger 2000mg dosage had noticeably less activity in the amygdala, insula, and lateral cortex. This diminished activity within these brain regions was seen to coincide with a decrease in levels of appetite amongst the individuals.

Should I Try Nootropics for Weight Loss?

When considering a nootropic for weight loss, it is first essential to consider how much weight you would like to lose. It is also crucial that you critically analyze your diet and eating patterns before attempting to assess things to change.

If you are someone who struggles with the temptation to eat too much and too often, perhaps nootropics can assist you in fighting off those urges.

Please note that there are many known natural appetite suppressants available. However, if you are someone who already benefits from the effects of nootropics or is interested in their wholistic effect, then read on.

Which Nootropics to Take for Weight Loss?

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Deciding the perfect nootropic for you lies in the ability to determine what your body needs. Often when we suffer from appetite irregularities the source may be related to dopamine neurons firing in a less optimal way. In this situation, it seems very plausible to think that nootropics can assist in decreasing food intake.


Citicoline is commonly found in nutritional supplements and is available in many health food stores around the globe. It is an organic compound that has been researched in animal and human subjects to show a clinical increase in;

  • Cognition
  • Neuroregeneration
  • Neuroprotection

Citicoline is even reported to have a significant impact on the elevation of motivation. This is demonstrated in preliminary research where Citicoline supplementing participants were significantly more likely to feel motivated and enthusiastic when confronted with a challenging task.


In the small intestine, ingested citicoline will undergo a process known as hydrolysis, resulting in the high absorption of choline and cytidine (95-100%). It is believed that these molecules then enter the brain via the blood-brain barrier to assist in the preservation of cell membrane phospholipid catabolism. This is achieved by increasing the synthesis of acetylcholine and phosphatidylcholine which are primary membrane components. While scientists are still not certain, it is thought that this process has an effect on the dopamine reward system which can lead to reduced cravings and diminished urges to eat.

The bottom line

Preliminary findings reveal that a dosage of 2000 mg/day of citicoline for a period of 6 weeks is associated with a significant drop in hunger amongst healthy patients. This supplement is readily available and passes the consumer health laws of many countries.


Did you know that coffee contains a complex chemical concoction of more than 1000 unique compounds?

We’ve all heard of it and probably have consumed it, however, 1,3,7-trimethylxanthine (caffeine) still holds many mysterious effects in the body that we are unfamiliar with. That being said, caffeine has been vigorously studied and is well-known for its ability to improve mental cognition, reaction speed, endurance, and additionally, weight loss. Yes, that’s right, weight loss too!

This has been identified through the noticeable increase in the number of calories burnt at rest in participants who had ingested caffeine [study]. But the fat-burning ability of caffeine doesn’t stop there!

It has also demonstrated the potential to improve the body’s capacity to metabolize fat cells, a process primarily achieved through increasing norepinephrine levels in the blood and increasing circulation to adipose tissue.

In effect, this encourages the body to prefer the breakdown of fat for energy. Moreover, some research appears to suggest unusual features about the effects of caffeine. Some studies now suggest that male subjects may react differently to the drug.

This is evident in one study that found that after consuming 300 mg of caffeine, men will likely decrease calorie consumption by up to 22% whereas this effect was not evident in female subjects.

Don’t worry ladies!

Studies continue to report that resting metabolic rate in both sex patients can be increased by 11% for up to 24 hours following ingestion. Regardless of gender! It should be noted that in these studies caffeine alone was not enough to induce overall weight loss results.

The bottom line

The decision to consume caffeine or not should primarily depend upon your personal preference as well as experience with caffeine.

While there is currently limited evidence to suggest that caffeine consumption amongst healthy users will produce any adverse side effects, anecdotal reports suggest that some individuals may experience negative impacts such as increased symptoms of anxiety and jitteriness.

Nevertheless, there is no doubt that caffeine can increase the metabolism of fat and thereby is useful for those trying to lose weight.  

Green Tea Extract

Green tea – well known for its nootropic substituent L-theanine, is speculated to contain several distinct compounds likely to enhance weight loss.

Much of the research around this topic focuses on catechins, particularly epigallocatechin gallate (EGCG) which are commonly extracted from the tea leaves and included in the many commercial weight loss supplements available in the store.

A quick search around the net shows that the fat-burning effect is heavily advocated by many in the bodybuilding industry and for good reason!

Popular research platform, PubMed reveals over 224 articles acknowledging the health-promoting benefits of green tea, with much of the research finding that it has an overall enhancing effect on weight loss. One of the more popularly cited articles state;

“On the basis of these results, one can advance the notion that EGCG is readily available and widely consumed and may have a high potential use in the prevention of metabolic syndrome.”

 (From Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome)   

The bottom line

EGCG (which is found in green tea), has been consistently observed to assist subjects aiming for weight loss. Studies using dosages of between 300–460 mg of EGCG for at least 12 weeks are shown to be the appropriate conditions for significant, noticeable increases in fat metabolism and weight loss.  


There you have it, the very best sourced nootropics that have all been clinically shown to possess fat-burning effects. All of which you can start using to assist you in your weight loss goals today!

Nootropics for weight loss is a growing area of research and future research should focus on other various naturally occurring nootropics to determine their effect on fat metabolism.

The prospect behind nootropics and their effects are exciting and it is quite possible that in the future these supplements may be recommended by doctors for their ability to assist in the prevention of mental health deterioration as well as weight loss!    

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1 Comment

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